ACI-RB

Benefit of ACI-RB
Product Introduction
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies. Aceclofenac potently inhibits the cyclo-oxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. It is orally administered for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

Aceclofenac belongs to BCS Class II as it possesses poor aqueous solubility. Aceclofenac displays high permeability to penetrate into synovial joints where in patients with osteoarthritis and related conditions, the loss of articular cartilage in the area causes joint pain, tenderness, stiffness, crepitus, and local inflammation.Aceclofenac is also reported to be effective in other painful conditions such as dental and gynaecological conditions. Aceclofenac was developed as an analog of a commonly prescribed NSAID.

Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. Rabeprazole is a prodrug ? in the acid environment of the parietal cells Rabeprazole turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. A specific blocker of dopamine receptors. Rabeprazole speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Indication of ACI-RB
Aceclofenac?

Indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. Rabeprazole is a prodrug ? in the acid environment of the parietal cells Rabeprazole turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.A specific blocker of dopamine receptors. Rabeprazole speeds gastrointestinal peristalsis, causes prolactin releas

Side Effects
Common side effects are Nausea, Flatulence, Indigestion, Diarrhea, Constipation